产品说明
应用
Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma .
生化/生理作用
PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways .
单位定义
One unit is defined as the amount of enzyme required to produce 1 μmol of NADP per minute at 37℃ in 50 mM KPO4 pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone
基本信息
| 酶学委员会(EC)编号 | 1.1.1.188 ( BRENDA | IUBMB ) |
| NACRES | NA.54 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in E. coli |
| 描述 | contains a C-terminal hexahistidine tag |
| 测定 | ≥90% (SDS-PAGE) |
| 形式 | liquid |
| specific activity | ≥0.4 μmol/mg protein |
| 分子量 | ~37 kDa |
| NCBI登记号 | NP_003730 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... AKR1C3(8644) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
