Anti-MAD2L1BP antibody produced in chicken

产品说明

免疫原

Immunogen Sequence: GI # 7661918, sequence 1-126
Recombinant MAD2L1 binding protein isoform 2

应用

Anti-MAD2L1BP antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生化/生理作用

MAD2L1-binding protein is a protein encoded by the MAD2L1BP gene in humans. MAD2 is a key component of the spindle checkpoint and is implicated in silencing the spindle assembly checkpoint after all kinetochores are attached to spindles. MAD2L1 overexpression in cells arrested by the spindle checkpoint causes premature destruction of securin and allows exit from mitosis without chromosome segregation. Its depletion induces cell death following a transient delay in the onset of anaphase. It interacts with the spindle checkpoint and coordinates cell cycle events in late mitosis.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

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