产品说明
一般描述
Growth-differentiation factor-15 (GDF-15) is a stress-responsive member of the transforming growth factor-β cytokine superfamily. It is also known as PTGF-Growth-differentiation factor-15 (GDF-15) and is a stress-responsive member of the transforming growth factor-β cytokine superfamily.2 It is also known as PTGF-β, TGF-PL or MIC-1β, TGF-PL or MIC-1.
应用
Growth-differentiation factor-15 (GDF-15) has been associated in the regulation of cell survival, proliferation, and differentiation and also in the protection from ischemia/reperfusion injury. Inflammatory and apoptotic pathways are regulated in injured tissues by GDFs during disease processes.
生化/生理作用
Although it has been classified as a divergent member of the transforming growth factor-β superfamily, GDF-15 shares structural characteristics with this superfamily. It has been identified as a biomarker for human prostate cancer. Additionally, increased GDF-15 expression has been observed in breast, pancreas and colorectal cancers. Functions of this cytokine include inhibition of TNF-α production, initiation of cartilage formation, and promotion of neuronal survival.
It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer.
外形
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile, 0.1% trifluoroacetic acid containing 50 μg of bovine serum albumin per 1 μg of GDF-15.
分析说明
Under reducing conditions in SDS-PAGE, each recombinant GDF-15 monomer migrates as an ~14 kDa protein.
基本信息
| NACRES | NA.26 |
产品性质
| 质量水平 | 100 |
| 生物来源 | human |
| 重组 | expressed in CHO cells |
| 测定 | >97% (visualized with silver stain, SDS-PAGE) |
| 形式 | lyophilized powder |
| 分子量 | dimer 13 kDa (based on N-terminal sequencing, starting at the first histidine of the 6X histidine tag) |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | endotoxin, tested |
| UniProt登记号 | Q99988 |
| 储存温度 | −20℃ |
| Gene Information | human ... GDF15(9518) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
