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Anti-GRP75 (SQ-15) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
G4045
规格纯度
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
参考价格
4731.57 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-GRP75 (SQ-15) antibody produced in rabbit
Anti-Mortalin
Anti-Mitochondrial Hsp70
Anti-Glucose Regulated Protein 75
Anti-Peptide Binding Protein 74
产品介绍:

产品说明

一般描述

GRPs are unresponsive to heat stress and are induced by stress related to glucose starvation or defects in glycoprotein processing. GRP75/mortalin has been localized mainly to the endoplasmic reticulum (ER), but also to various cellular compartments including mitochondria and cytoplasmic vesicles.
GRP75 (glucose-regulated protein 75) belongs to a Hsp70 family of the heat shock proteins.

免疫原

synthetic peptide corresponding to amino acids 665-679 located at the C-terminus of human GRP75. This sequence is identical in mouse GRP75 (mot-1 and mot-2 isoforms) and highly conserved in rat (1 amino acid substitution).

应用

Anti-GRP75 antibody produced in rabbit has been used in :

  • immunofluorescence
  • immunoblotting
  • immunocytochemistry

生化/生理作用

GRP75 (glucose-regulated protein 75) is involved in stress responses to intracellular trafficking, antigen processing, and control of cell proliferation, differentiation, and tumorigenesis. It is induced by low levels of ionizing radiation, glucose deprivation, calcium ionophore, and ozone and its levels correlate with muscle activity, mitochondrial activity, and biogenesis.
Heat shock proteins (HSP) are considered to function as molecular chaperones by transiently binding to newly synthesized proteins to facilitate their correct folding and assembly. GRP75 levels are associated with muscle activity, mitochondrial function and biogenesis.

目标描述

GRP75 (SQ-15) encodes a heat-shock cognate protein. This protein plays a role in the control of cell proliferation.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00164609
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 75 kDa
species reactivitycanine, mouse, human
浓度~1 mg/mL
technique(s)indirect immunofluorescence: 1-2 μg/mL using HeLa cells
western blot: 0.2-0.4 μg/mL using whole cell extracts of HeLa, MDCK, and NIH3T3 cells
UniProt登记号P38646
运输dry ice
储存温度−20℃
Gene Informationmouse ... Hspa9(15526)
rat ... Hspa9(291671)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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