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位置:首页 > 品牌 > Sigma-Aldrich > 5-氯-2′-脱氧尿苷

5-Chloro-2′-deoxyuridine

5-氯-2′-脱氧尿苷

品牌
Sigma-Aldrich
CAS
50-90-8
货号
C6891
规格纯度
thymidine analog
参考价格
1115.17 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
50-90-8
5-Chloro-2′-deoxyuridine
CldU
5-氯-2′-脱氧尿苷
产品介绍:

产品说明

应用

5-Chloro-2′-deoxyuridine has been used to:

  • study cell cycle dynamics by immunohistochemical analysis and double S-phase labeling using animal models
  • analyze cell cycle length using an animal model
  • label HEK293T cells for molecular combing assay

包装

100 mg in poly bottle

生化/生理作用

DNA labeled with 5-chloro-2′-deoxyuridine (CldU) serves as an effective tool to analyze and quantify DNA replication, repair, and recombination. CldU is a potent mutagen, clastogen, and toxicant. It is used as a thymidine analog and is found to alter the dNTP pools and might lead to cell-cycle arrest. CldU produces sister-chromatid exchange but has less response to ionizing radiation compared to other thymine analogs. 5-Chloro-2′-deoxyuridine (CldU) is used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).

基本信息

经验(实验)分子式C9H11ClN2O5
分子量262.65
MDL编号MFCD00006531
PubChem化学物质编号24892910
NACRESNA.51

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
溶解性1 M NH4OH: 20 mg/mL, clear, colorless to faintly yellow
储存温度−20℃
SMILES stringOC[C@H]1O[C@H](C[C@@H]1O)N2C=C(Cl)C(=O)NC2=O
InChI1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI keyNJCXGFKPQSFZIB-RRKCRQDMSA-N

安全信息

象形图GHS07GHS08
警示用语:Warning
危险声明H302 + H312 + H332 - H351
预防措施声明P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
危险分类Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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