产品说明
一般描述
A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
A derivative of papaverine that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Inhibits the entry of Ca2+ through voltage-dependent Ca2+ channels in cell membranes. Blocks both activated and inactivated Ca2+ channels. An adrenergic antagonist. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
包装
100 mg in Alu drum
生化/生理作用
Product does not compete with ATP.
Reversible: no
Cell permeable: no
警告
Toxicity: Toxic (F)
其他说明
Lonsberry, B.B., et al. 1994. Pharmacology 49, 23.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.
Janis, R., et al. 1987. Adv. Drug Res.16, 309.
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法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C27H38N2O4 · xHCl |
| 分子量 | 454.60 (free base basis) |
| MDL编号 | MFCD00055208 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥99% (perchloric acid titration) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze |
| 颜色 | white |
| 溶解性 | methanol: 50 mg/mL water: 70 mg/mL ethanol: soluble |
| 运输 | ambient |
| 储存温度 | 10-30℃ |
| InChI | 1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H |
| InChI key | DOQPXTMNIUCOSY-UHFFFAOYSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H301 - H411 |
| 预防措施声明 | P264 - P270 - P273 - P301 + P310 - P391 - P405 |
| 危险分类 | Acute Tox. 3 Oral - Aquatic Chronic 2 |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
