Indomethacin-CAS 53-86-1-Calbiochem

产品名称：

53-86-1
Indomethacin-CAS 53-86-1-Calbiochem
1-( p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid
1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid

产品介绍：

产品说明

一般描述

A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC₅₀ = 740 nM for COX-1; IC₅₀ = 970 nM for COX-2). Inhibits phospholipase A₂(IC₅₀ = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells.
A cell-permeable, non-steroidal anti-inflammatory, anti-pyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC₅₀ = 740 nM for COX-1; IC₅₀ = 970 nM for COX-2). Inhibits phospholipase A₂ (IC₅₀ = 145 µM). Reported to reduce Aβ₄₂ levels independently of COX activity.

包装

10 g in Alu drum

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

其他说明

Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun.281, 483.
Weggen, S., et al. 2001. Nature414, 212.
Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 925.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
Oliw, E. 1980. Prostaglandins19, 271.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₉H₁₆ClNO₄
分子量	357.79
MDL编号	MFCD00057095

产品性质

质量水平	100
测定	≥98% (by assay)
形式	powder
效能	740 nM IC₅₀
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	white to off-white
溶解性	ethanol: 20 mg/mL
运输	ambient
储存温度	10-30℃
InChI	1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChI key	CGIGDMFJXJATDK-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H300
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 1 Oral
储存分类代码	6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable