产品说明
一般描述
Interleukin-4 (IL-4) is a pleiotropic cytokine and a complex glycoprotein mapped to human chromosome 5q31.1. It is produced by mast cells, basophils and a subset of activated T cells.
包装
10 μg in poly bottle
生化/生理作用
Interleukin-4 (IL-4) interacts with interleukin 13 and is an interleukin-4 receptor ligand. It regulates IgE and IgG1 production by B cells. IL-4 favors glial and neuronal differentiation and regulates differentiation of naive cluster of differentiation CD4+ T cells to the T helper type 2 (TH2) cells. Polymorphism in the IL-4 gene is implicated in immune and inflammatory disorders. In cerebral infarction, IL-4 levels are elevated.
外形
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
制备说明
HumanKine Interleukin-4 (IL-4), expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 14-19 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
分析说明
The specific activity was determined by the dose-dependent simulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
法律信息
HumanKine is a registered trademark of Proteintech Group, Inc.
基本信息
| MDL编号 | MFCD00151705 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 生物来源 | human |
| 重组 | expressed in HEK 293 cells |
| 测定 | >95% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | ≤0.6 ng/mL EC50 |
| 质量 | endotoxin tested |
| 分子量 | dimer 14-19 kDa (glycosylated) |
| 包装 | pkg of 1 mg pkg of 10 μg pkg of 100 μg |
| manufacturer/tradename | HumanZyme |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | <1 EU/μg |
| UniProt登记号 | P05112 |
| 储存温度 | −20℃ |
| Gene Information | human ... IL4(3565) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
