产品说明
一般描述
Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.
生化/生理作用
Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.
外形
Solution in phosphate buffered saline containing 30% glycerol.
分析说明
Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.
The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.
基本信息
| MDL编号 | MFCD01867052 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human |
| 重组 | expressed in E. coli |
| 测定 | ≥80% (SDS-PAGE) |
| 形式 | buffered aqueous glycerol solution |
| 分子量 | 185 kDa |
| 包装 | pkg of 100 μg |
| 储存条件 | avoid repeated freeze/thaw cycles |
| UniProt登记号 | Q02297 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... NRG1(3084) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
