产品说明
一般描述
Hepatitis C virus core antigen (HCV-cAg) is a well-preserved antigenic protein of the internal capsid.
Hepatitis C virus glycoprotein 1 (HCVgp1), also referred to as polyprotein, is crucial for the induction of double-membrane vesicles, sites of HCV RNA amplification. The amino terminal of polyprotein contains the structural proteins core, envelope protein 1 (E1) and E2. The proteolytic cleavage of polyprotein results in the formation of 10 mature viral proteins which are needed for viral replication and assembly.
amino acids 2-192 of HCV polyprotein
特异性
Reacts strongly with human HCV positive serum.
应用
Hepatitis core antigen (HCA) has been used as an analyte in enzyme-linked immunosorbent assay (ELISA) to study the mechanism of bovine serum albumin (BSA) blocking in common ELISA protocols.
生化/生理作用
Hepatitis C virus core antigen (HCV-cAg) may be a less expensive way to diagnose active hepatitis C virus (HCV) infection in the hemodialysis (HD) population.
Positive control for HCV antibodies.
其他说明
HCV core antigen [2-192]-Galactosidase-tagged at the N-terminus.
外形
Solution in 8 M Urea, 20 mM Tris-HCl, pH 8.0, 10 mM 2-mercaptoethanol.
基本信息
| MDL编号 | MFCD02264926 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in E. coli |
| 测定 | ≥95% (SDS-PAGE) |
| 分子量 | 22 kDa (plus 114 kDa galactosidse) |
| 浓度 | ~1 mg/mL |
| UniProt登记号 | G9G988 L7S4V3 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | hepatitis C virus ... HCVgp1(951475) human ... HBVgp4(944568) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
