产品说明
一般描述
HCVgp1 (hepatitis C virus glycoprotein 1), also referred to as polyprotein, is crucial for the induction of double-membrane vesicles, which are sites of HCV RNA amplification. The amino terminal of polyprotein contains the structural proteins core, envelope protein 1 (E1) and E2. The proteolytic cleavage of polyprotein results in the formation of 10 mature viral proteins, including NS4 (non-structural 4).
β-gal fused at N-terminus
生化/生理作用
NS4 (non-structural 4) mainly acts a cofactor for the NS3 serine protease, which is needed for the cleavage of the non-structural area of the polyprotein. It also suppresses host cell translation as well as proliferation. In addition, it induces anti-inflammatory cytokines and thereby suppresses cellular immune responses.
Positive control for HCV antibodies.
其他说明
HCV NS4a+b [1658-1863]-Galactosidase-tagged, rhodamine conjugate.
外形
Solution in 8 M urea, 20 mM tris-HCl, pH 8.0, and 10 mM 2-mercaptoethanol.
基本信息
| MDL编号 | MFCD02264902 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in E. coli |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | solution |
| 分子量 | 19 kDa (plus 114 kDa β-Gal tag) |
| 浓度 | ~1 mg/mL |
| UniProt登记号 | L7S4V3 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | hepatitis C virus ... HCVgp1(951475) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
