产品说明
一般描述
M-CSF is encoded by the gene mapped to human chromosome 1p13.3. It is a glycosylated polypeptide, which exists as a homodimer. M-CSF is produced by macrophage, fibroblasts, lymphocyte and endothelial cells.
包装
10 μg in poly bottle
生化/生理作用
Macrophage CSF (M-CSF) as a growth factor, stimulates the proliferation and differentiation of monocyte/macrophage-lineage cells. It also boosts antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages. In addition, human M-CSF inhibits bone resorption by osteoclasts. It might also play a crucial role in atherosclerosis. Overexpression of the gene has been observed in Paget′s disease of bone (PDB).
外形
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
分析说明
The specific activity was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells (mouse myeloid Leukemia indicator cell line).
引用
1. Mazur, E.M., and Cohen, J.L., Clin. Pharmacol. Ther., 46, 250 (1989).
2. Morstyn, G., and Burgess, A.W., Cancer Res., 48, 5624 (1988).
3. Metcalf, D., Blood, 67, 257 (1986).
4. Mufson, R.A., et al., Cell. Immunol., 119, 182 (1989).
5. Hattersley, G., et al., J. Cell Physiol., 137, 199 (1988).
法律信息
HumanKine is a registered trademark of Proteintech Group, Inc.
基本信息
| MDL编号 | MFCD00166591 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 生物来源 | human |
| 重组 | expressed in HEK 293 cells |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | ≤4 ng/mL EC50 |
| 质量 | endotoxin tested |
| 分子量 | dimer 35-40 kDa (glycosylated) |
| 包装 | pkg of 10 μg |
| manufacturer/tradename | HumanZyme |
| technique(s) | cell culture | mammalian: suitable |
| UniProt登记号 | P09603 |
| 储存温度 | −20℃ |
| Gene Information | human ... CSF1(1435) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
