三甲基（三氟甲基）硅烷溶液

产品名称：

81290-20-2
Trimethyl(trifluoromethyl)silane solution
(Trifluoromethyl)trimethylsilane
Ruppert′s reagent
Trifluoromethyltrimethylsilane
Ruppert-Prakash Reagent
TFMTMS
三甲基（三氟甲基）硅烷溶液

产品介绍：

产品说明

一般描述

Trimethyl(trifluoromethyl)silane (TMSCF₃) is also called as Ruppert-Prakash fluorination reagent. It is extensively used for the synthesis of trifluoromethyl-containing compounds.

应用

Reactant for:

Silver-mediated C-H trifluoromethylation of arenes
Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8
Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts
Palladium-catalyzed oxidative trifluoromethylation of indoles
Preparation of 5-HT1A antagonists

Used as difluorocarbene source

TMSCF₃ can be used as a reagent for:

Conversion of aromatic aldehydes to difluoromethylated products.
C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction.

It can also be used in trifluoromethylation of:

Non-activated aldimines.
Heterocumulenes.
Azomethine imines.

包装

10, 50 mL in glass bottle

基本信息

线性分子式	(CH₃)₃SiCF₃
分子量	142.19
Beilstein	4241868
MDL编号	MFCD00145454
PubChem化学物质编号	57653455
NACRES	NA.22

产品性质

形式	liquid
质量水平	100
reaction suitability	reaction type: C-C Bond Formation
浓度	2 M in THF
折射率	n20/D 1.386
密度	0.91 g/mL at 20 ℃
SMILES string	C[Si](C)(C)C(F)(F)F
InChI	1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
InChI key	MWKJTNBSKNUMFN-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H225 - H302 - H319 - H335 - H351
预防措施声明	P210 - P280 - P301 + P312 + P330 - P305 + P351 + P338 - P370 + P378 - P403 + P235
危险分类	Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
靶器官	Respiratory system
补充剂危害	EUH019
储存分类代码	3 - Flammable liquids
WGK	WGK 3
闪点(F)	1.4 °F
闪点(C)	-17 ℃
个人防护装备	Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Trimethyl(trifluoromethyl)silane solution

三甲基（三氟甲基）硅烷 溶液

三甲基（三氟甲基）硅烷溶液