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Anti-Adiponectin Antibody

品牌
Sigma-Aldrich
货号
AB3784P-I
规格纯度
from rabbit, purified by affinity chromatography
参考价格
5097.31 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Adiponectin Antibody
Adiponectin, 30 kDa adipocyte complement-related protein, ACRP30, Adipocyte complement-related 30 kDa protein, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein
产品介绍:

产品说明

一般描述

Adiponectin (UniProt Q15848; also known as 30 kDa adipocyte complement-related protein, ACRP30, Adipocyte complement-related 30 kDa protein, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein) is encoded by the ADIPOQ (also known as ACDC, ACRP30, ADPND, APM1, GBP28) gene (Gene ID 9370) in human. Adipokines are adipose tissue-secreted factors that are involved in vascular function and metabolic disease. While most adipokines are proinflammatory and directly responsible for the development of the chronic inflammatory state in obesity, adiponectin is an adipokine with anti-inflammatory and insulin-sensitizing properties. Adiponectin mediates its biological activity via adiponection receptor proteins 1 & 2 (AdipoR1 & AdipoR2). Both AdipoR1 and AdipoR2 are reported to be ubiquitously expressed with the highest expression in skeletal muscle and liver, respectively. Circulating adiponectin levels are reduced in obesity and type II diabetes, whereas weight loss elevates serum levels of adiponectin. Likewise, adiponectin overexpression is reported to alleviate metabolic dysfunction independent of weight loss in both genetic and diet-induced animal models of obesity. Aadiponectin deficiency is associated with various clinical cardiovascular disorders including myocardial infarction, peripheral artery disease, and endothelial dysfunction. Adiponectin is produced with a signal peptide sequence (a.a. 1-18 in human and rat sequence; a.a. 1-17 in mouse), which is removed postranslationally to yield the mature protein with a collagen-like domain (a.a. 42-107 in human and rat, a.a. 45-110 in mouse) and a C1q domain (a.a. 108-244 in human and rat, a.a. 111-247 in mouse).

特异性

This polyclonal antibody targets the C1q domain (globular domain) of human adiponectin.

免疫原

GST-tagged recombinant human adiponectin C1q domain (globular domain) fragment.

应用

Detect adiponectin using this rabbit Anti-Adiponectin polyclonal antibody, Cat. No. AB3784P-I, validated for use in Immunohistochemistry and Western Blotting.
Research Category
Signaling
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected adiponectin in human heart, kidney, and uterus tissue sections.

质量

Evaluated by Western Blotting of human plasma proteins.

Western Blotting Analysis: A 1:500 dilution of this antibody detected adiponectin in 10 µg of human plasma proteins.

目标描述

~32 kDa oberved. Target band size appears larger than the calculated molecular weight of 26.41/24.54 kDa (with/without signal peptide a.a. 1-18 sequence) due to posttranslational modifications. Uncharacterized bands may be observed in some lysate(s).

联系

Replaces: AB3784P

外形

Affinity purified.
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivityhuman
technique(s)immunohistochemistry: suitable
western blot: suitable
NCBI登记号NP_004788
UniProt登记号Q15848
运输ambient
Gene Informationhuman ... ADIPOQ(9370)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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