产品说明
一般描述
IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains. It is a secreted protein.
生化/生理作用
IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation. It mainly binds to IGFs and restricts their association to other receptors.
During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.
外形
Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA.
分析说明
The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.
基本信息
| MDL编号 | MFCD02099094 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 重组 | expressed in NSO cells |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | 0.125-0.5 mg per mL ED50 |
| 分子量 | ~35 kDa by SDS-PAGE (reducing) calculated mol wt 29.4 kDa |
| 包装 | pkg of 25 μg |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | endotoxin, tested |
| UniProt登记号 | D3YU40 |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Igfbp2(16008) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
