产品说明
一般描述
The gene IGFBP-5 (insulin-like growth factor binding protein-5) is mapped to human chromosome 2q35.
包装
25 μg in glass insert
生化/生理作用
IGFBP-5 binds to bone cells and is the predominant insulin-like growth factor binding protein in bone. When IGFBP-5 binds the extracellular matrix, it modulates IGF activity. Mouse, human, and rat IGFBP-5 share 97% homology.
IGFBP-5 (insulin-like growth factor binding protein-5) interacts with IGFs and thereby controls IGF activity. High levels of IGFBP5 are present in systemic sclerosis and idiopathic pulmonary fibrosis conditions. It also plays a crucial role in cancer progression.
外形
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.
分析说明
The biological activity is measured by its ability to inhibit recombinant human IGF-1 or IGF-II on MCF-7 cells.
基本信息
| MDL编号 | MFCD03457235 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 100 |
| 生物来源 | human |
| 重组 | expressed in NSO cells |
| 测定 | >90% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | 0.5-1.5 mg per mL ED50 |
| 分子量 | 34 kDa by SDS-PAGE (reducing) calculated mol wt ~28 kDa |
| 包装 | pkg of 25 μg |
| 杂质 | endotoxin, tested |
| UniProt登记号 | P24593 |
| 储存温度 | −20℃ |
| Gene Information | human ... IGFBP5(3488) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
