产品说明
一般描述
The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. The encoded protein is extensively glycosylated and contains five Ig-like domains that share high homology with corresponding domains in ICAM-1 and ICAM-2. ICAM3 is found to be expressed on all leukocytes, including the resting leukocytes. The gene is mapped to human chromosome 19p13.2.
免疫原
stimulated human leukocytes.
生化/生理作用
The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. LFA-1 participates in several processes, such as T cell-mediated killing, T helper and B lymphocyte responses, natural killing, Ab-dependent cellular cytotoxicity by monocytes and granulocytes, and adherence of leukocytes to endothelial cells, fibroblasts, and epithelial cells. ICAM-3 mediates the adhesion of resting T lymphocytes to LFA-1 and participates in the initiation of immune responses. It may also function in lymphocyte activation, as well as in adhesion.
外形
Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide.
基本信息
| MDL编号 | MFCD01094485 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 186-2G9, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 120 kDa |
| species reactivity | human |
| 浓度 | ~1 mg/mL |
| technique(s) | direct immunofluorescence: 2 μg using 1 mg protein lysate flow cytometry: 2 μg using 1 mg protein lysate immunohistochemistry: 2-4 μg/mL using human tonsil tissue sections immunoprecipitation (IP): 2 μg using 1 mg protein lysate western blot: 1-5 μg/mL |
| UniProt登记号 | P32942 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ICAM3(3385) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
