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Insulin-like Growth Factor-I Receptor human

品牌
Sigma-Aldrich
货号
I4657
规格纯度
≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
参考价格
12107.8 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Insulin-like Growth Factor-I Receptor human
IGF-I Receptor
产品介绍:

产品说明

一般描述

IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies.

应用

Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.

生化/生理作用

IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.

外形

Lyophilized from a 0.2 μm solution in phosphate buffered saline.

分析说明

The biological activity is measured by its ability to bind human IGF­-­I in a functional ELISA assay.
As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.

基本信息

MDL编号MFCD01323726
NACRESNA.32

产品性质

质量水平200
生物来源human
重组expressed in NSO cells
测定≥95% (SDS-PAGE)
形式lyophilized powder
分子量α-chain ~120 & 150 kDa
β subunit ~46 & 50 kDa
包装pkg of 50 μg
杂质 endotoxin, tested
UniProt登记号P08069
储存温度−20℃
Gene Informationhuman ... IGF1R(3480)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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