产品说明
生化/生理作用
Interleukin 17 (IL-17), initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
IL-17 (interleukin-17) participates in the activation of nuclear factor-κB and mitogen-activated protein kinase pathways and CCAAT/enhancer-binding protein family of transcription factors, thereby regulating pro-inflammatory and antimicrobial genes. In rheumatoid arthritis, IL-17 is responsible for the inflammation as well as destruction of joints.
外形
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg of bovine serum albumin.
分析说明
The biological activity of mouse IL-17 is measured by its ability to induce IL-6 production using NIH/3T3 cells.
基本信息
| MDL编号 | MFCD01635117 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 重组 | expressed in E. coli |
| 测定 | ≥97% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 分子量 | 16.5 kDa |
| 包装 | pkg of 25 μg |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | endotoxin, tested |
| UniProt登记号 | Q62386 |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Il17a(16171) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
