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Anti-Potassium Channel K2P1.1 (TWIK-1) antibody produced in rabbit

Anti-Potassium Channel K2P1.1 (TWIK-1) 兔抗

品牌
Sigma-Aldrich
货号
K0390
规格纯度
affinity isolated antibody, lyophilized powder
参考价格
4731.57 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Potassium Channel K2P1.1 (TWIK-1) antibody produced in rabbit
Anti-Inward rectifying potassium channel TWIK-1
Anti-Potassium Channel K2P1.1 (TWIK-1) 兔抗
产品介绍:

产品说明

一般描述

The gene K2P1.1 (two pore domain K+ channel), also referred to as KCNK1 (potassium two pore domain channel subfamily K member 1), encodes a protein that spans a length of 337-amino acids. It contains four transmembrane regions and the characteristic sequence of potassium channels in the two pore regions. The protein is found to be exclusively expressed in distal tubule. The gene is mapped to human chromosome 1q42.2.

免疫原

synthetic peptide RQELRKLKRRFLEEHEC, corresponding to amino acid residues 53-69 of human K2P1.1 (KCNK1).

生化/生理作用

The gene KCNK1 (potassium two pore domain channel subfamily K member 1) is a double-pore potassium channel that functions in maintaining the renal potassium homeostasis. KCNK channel proteins are involved in cell volume, apoptosis, and proliferation. Alterations in these proteins have been associated with various diseases. Decreased levels of KCNK1 in human cardiac atria have been implicated in chronic atrial fibrillation. It functions as a suppressor of anchorage-independent growth in fibroblast.

目标描述

K2P1.1 (also named TWIK-1 or KCNK1) is a member of the 2-pore (2P) domain K+ channels family that at the moment includes 14 members. These channels show little time or voltage dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents, which help set the membrane resting potential and cell excitation.

外形

Lyophilized from pphosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

重悬

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式lyophilized powder
species reactivitymouse, human, rat
technique(s)immunohistochemistry: suitable
western blot: 1:200 using rat brain lysates
western blot: 1:300 using HEK-K2P1.1 transfected cells
UniProt登记号O00180
运输dry ice
储存温度−20℃
Gene Informationhuman ... KCNK1(3775)
mouse ... Kcnk1(16525)
rat ... Kcnk1(59324)

安全信息

储存分类代码13 - Non Combustible Solids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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