产品说明

一般描述

The gene Kcnh8 (potassium voltage-gated channel subfamily H member 8), also referred to as Elk1/Ets-1, belongs to the Ets family of transcription factors. The members of this subfamily are part of the ether-a-go-go (EAG) family of potassium channel pore-forming subunits. The rat elk mRNA is found to be expressed in brain. The rat elk subunits contain six hydrophobic membrane-spanning segments S1-S6, a P-domain, and a motif homologous to cyclic nucleotide-binding domains at the C-terminus.

免疫原

peptide EDKKEDRAKGRSRAG(C) corresponding to amino acid residues 143-157 of rat K_V12.1.

生化/生理作用

The gene Kcnh8 (potassium voltage-gated channel subfamily H member 8) encodes a potassium channel pore-forming subunit that activates p21WAF1/Cip1 via cis-acting elements in p21WAF1/Cip1 and inhibits apoptosis of vascular smooth muscle cells. The potassium channel is found to mediate slowly activating sustained potassium currents.

目标描述

K_v12.1 channel is confined mainly to the central nervous system with some expression in peripheral organs such as testis, colon and lung. The physiological function of the K_v12.1 channel hasn′t been established, although a role in the modulation of overall excitability of neurons has been suggested.

外形

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

重悬

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息

象形图
警示用语：	Warning
危险声明	H312 - H412
预防措施声明	P280
危险分类	Acute Tox. 4 Dermal - Aquatic Chronic 3
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable