产品说明
一般描述
PKCθ (protein kinase C θ) is a serine/threonine kinase, belonging to protein kinase C family.
生化/生理作用
PKCθ (protein kinase C θ) is required for T cell activation and proliferation. In presence of TCR (T cell receptor) stimulation, it is responsible for activation of NF-AT (nuclear factor of activated T-cells), NF-κB (nuclear factor κ B) and AP1 (adaptor-related protein complex 1). It might be a target for the treatment of type 2 diabetes. PKCθ is needed for fat-mediated insulin resistance in skeletal muscle.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
基本信息
NACRES | NA.32 |
产品性质
质量水平 | 200 |
重组 | expressed in baculovirus infected Sf9 cells |
产品线 | PRECISIO® Kinase |
测定 | ≥70% (SDS-PAGE) |
形式 | buffered aqueous glycerol solution |
specific activity | 673-911 nmol/min·mg |
分子量 | ~110 kDa |
UniProt登记号 | Q04759 |
运输 | dry ice |
储存温度 | −70℃ |
Gene Information | human ... PRKCQ(5588) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich