产品说明
应用
LP44 has been used as a 5-hydroxytryptamine (serotonin) receptor 7 (5-HT7) agonist to study its effects on mitochondria-mediated leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammasome activation.
包装
10, 50 mg in glass bottle
生化/生理作用
LP44 is a high affinity 5-HT7 receptor agonist. Ki = 0.22 nM. LP44 displays selectivity over 5-HT1A and 5-HT2A receptors (200- and >1000-fold, respectively). LP44 induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).
基本信息
| 经验(实验)分子式 | C27H38ClN3OS |
| 分子量 | 488.13 |
| MDL编号 | MFCD09971090 |
| PubChem化学物质编号 | 329817675 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 溶解性 | DMSO: >10 mg/mL H2O: ≥2 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | Cl.CSc1ccccc1N2CCN(CCCCCC(=O)NC3CCCc4ccccc34)CC2 |
| InChI | 1S/C27H37N3OS.ClH/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24;/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31);1H |
| InChI key | DWGKCWWWKHCVDH-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
