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Lactoferrin from bovine colostrum

乳铁蛋白 来源于牛初乳

品牌
Sigma-Aldrich
CAS
936541-36-5
货号
L4765
规格纯度
≥85% (SDS-PAGE)
参考价格
1241.11 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
936541-36-5
Lactoferrin from bovine colostrum
乳铁蛋白 来源于牛初乳
产品介绍:

产品说明

一般描述

Lactoferrin from bovine colostrum corresponds to a molecular weight of 80 kDa. It is a glycosylated protein and belongs to the transferrin family. Bovine lactoferrin has N and C-terminal lobes homologous to human lactoferrin.

应用

Lactoferrin from bovine colostrum was used in the characterization of lactoferrin (lf) from colostral whey using anti-lf antibody immunoaffinity chromatography. It was used in the isolation of lactoferrin from bovine colostrum using ultrafiltration coupled with strong cation exchange chromatography.
Lactoferrin from bovine colostrum has been used as standard protein in sodium dodecyl sulfate (SDS)- polyacrylamide gel electrophoresis (PAGE) for the quantification of IgG samples. It has also been used to test its effect in inducing autoimmune pancreatitis.

包装

10, 50 mg in poly bottle

生化/生理作用

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

基本信息

MDL编号MFCD00131481
NACRESNA.61

产品性质

质量水平200
生物来源bovine colostrum
测定≥85% (SDS-PAGE)
形式powder
分子量 ~90 kDa
technique(s)electrophoresis: suitable
ion chromatography: suitable
杂质 salt, essentially free
溶解性H2O: soluble 5 mg/mL
UniProt登记号P24627
储存温度2-8℃
Gene Informationcow ... LTF(280846)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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