产品说明
一般描述
Luotonin B is a heteroaromatic pyrroloquinazolinoquinoline alkaloid that, along with Luotonin A and E, was originally isolated from the Chinese medicinal plant Paganum nigellastrum. It is an oxidation product of Luotonin A and is converted to Luotonin E by methanol treatment.
包装
10 mg in glass bottle
50 mg in poly bottle
生化/生理作用
Luotonin compounds have antitumor activity and demonstrate cytotoxicity and inhibitory activity against human topoisomerase. For use as a topoisomerase inhibitor, a starting concentration of 25 μM is suggested. It is suggested that a dose-response curve be performed to find the inhibitor concentration most suitable for the intended assay.
重悬
Solubility is tested at 2 mg/mL in 4:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.
基本信息
| 经验(实验)分子式 | C18H11N3O2 |
| 分子量 | 301.30 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 200 |
| 生物来源 | synthetic (organic) |
| 测定 | ≥98% |
| 形式 | solid |
| 溶解性 | chloroform/methanol (4:1): 2 mg/mL, clear to slightly hazy, colorless to yellow |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... TOP1(7150) |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H301 |
| 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 |
| 危险分类 | Acute Tox. 3 Oral |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
