产品说明
一般描述
Luotonin E is a heteroaromatic pyrroloquinazolinoquinoline alkaloid that, along with Luotonin A and B, was originally isolated from the Chinese medicinal plant Paganum nigellastrum. Luotonin compounds have antitumor activity and demonstrate cytotoxicity and inhibitory activity against human topoisomerase. For use as a topoisomerase inhibitor, a starting concentration of 25 μM is suggested. It is suggested that a dose-response curve be performed to find the inhibitor concentration most suitable for the intended assay.
包装
10 mg in glass bottle
50 mg in poly bottle
生化/生理作用
Luotonin E exhibited strong cytotoxic effects specifically on human leukemia P-388 cells.
重悬
Solubility is tested at 4 mg/mL in 4:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.
基本信息
| 线性分子式 | C19H13N3O2 |
| 分子量 | 315.33 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 200 |
| 生物来源 | synthetic (organic) |
| 测定 | ≥98% |
| 形式 | solid |
| 溶解性 | chloroform/methanol (4:1): 4 mg/mL, clear to slightly hazy, colorless to yellow |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... TOP1(7150) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 - H335 |
| 预防措施声明 | P261 - P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
