Anti-Mitofusin-1 Antibody

产品说明

一般描述

Along with Mitofusin-2 (Mfn2), Mitofusin-1 (Mfn1) is a known protein mediator of mitochondrial fusion. Mitochondrial fusion regulates mitochondrial morphogensis and supports complementation between mitochondrial genomes in mammalian cells. Two Mfn1 transcripts are detected at similar levels in a variety of human tissues and are dramatically elevated in the heart. Human Mfn1 is known to be localized in the mitochondria. It is reported that point mutations in the conserved G1 and G2 region of the Mfn1 GTPase domain result in decreased formation and fragmentation of the mitochondria, respectively.

特异性

This antibody recognizes Mitofusin-1 at the cytoplasmic domain.

免疫原

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Mitofusin-1.
Epitope: Cytoplasmic Domain

应用

Research Category
Cell Structure
Detect Mitofusin-1 using this Anti-Mitofusin-1 Antibody validated for use in WB.
Research Sub Category
Organelle & Cell Markers

质量

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Mitofusin-1 in 10 µg HeLa cell lysate.

目标描述

~86 kDa observed.
Three isoforms of Mitofusin-1 are produced by alternative splicing with molecular weights of ~42 kDa, ~71 kDa, and ~84 kDa Uncharacterized bands may appear at ~45 kDa, ~48 kDa, and ~55 kDa in some lysates.

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
HeLa cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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