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Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit

Anti-Monoamine Oxidase B (C-terminal) 兔抗

品牌
Sigma-Aldrich
货号
M1946
规格纯度
affinity isolated antibody, ~1.5 mg/mL, buffered aqueous solution
参考价格
6680.41 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit
Anti-MAO, brain
Anti-MAO, platelet
Anti-Adrenalin oxidase
Anti-Tyramine oxidase
Anti-Monoamine Oxidase B (C-terminal) 兔抗
产品介绍:

产品说明

一般描述

Anti-Monoamine Oxidase B (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to human monoamine oxidase B (MAO-B) conjugated to KLH. Monoamine oxidases (MAOs) are mitochondrial flavoprotein enzymes, localized to the mitochondrial outer membrane. MAO-B is mainly found in the brain in dopaminergic, serotonergic and histaminergic neurons, as well as in astrocytes. It is a member of the flavin monoamine oxidase family. MAOB gene is mapped to human chromosome Xp11.

特异性

Anti-Monoamine Oxidase B (C-terminal) specifically recognizes human, mouse and rat MAO-B.

应用

Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit may be used in immunoblotting.

生化/生理作用

Monoamine oxidases (MAOs) are the main degradative enzymes responsible for the oxidative deamination of biogenic amines, such as epinephrine, norepinephrine, serotonin (5-HT) and dopamine in the central nervous system (CNS) and peripheral tissues. MAO-B is considered the predominant isoform responsible for dopamine metabolism in the human CNS. It participates in the metabolism of neuroactive and vasoactive amines. MAO-B activity correlates with personality traits. Alterations in MAO-B activity may underlie dopamine pathobiology in major depression. Selective MAO-B inhibitors elevate synaptosomal dopamine concentrations and have recently shown clinical efficacy in the treatment of early Parkinson′s disease.

外形

Supplied as a solution in 0.01 M PBS, pH 7.4, containing 15 mM sodium azide as a preservative.

储存及稳定性

For continuous use, store at 2-8 ℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~58 kDa
species reactivityhuman, rat, mouse
包装antibody small pack of 25 μL
增强验证recombinant expression
Learn more about Antibody Enhanced Validation
浓度~1.5 mg/mL
technique(s)western blot: 0.25-0.5 μg/mL using rat liver mitochondrial fraction and HEK-293T cells expressing human MAO-B
UniProt登记号P27338
运输dry ice
储存温度−20℃
Gene Informationhuman ... ASCC3(10973), MAOB(4129)
rat ... Maob(25750)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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