产品说明
一般描述
Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on chromosome 11.
生化/生理作用
Matrix metalloproteinase-12 (MMP-12) breaks down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.
MMP-12 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.
单位定义
One unit equals 100 pmol/min at 37 ℃ using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-Leu-Gly-OEt as substrate.
外形
Solution in 50 mM Tris, 5 mM calcium chloride, 500 mM sodium chloride, 20 μM zinc chloride, 0.5% Brij® L23, and 30% glycerol, pH 9.5.
法律信息
Brij is a registered trademark of Croda International PLC
基本信息
| MDL编号 | MFCD02688053 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in E. coli |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | buffered aqueous glycerol solution |
| 分子量 | calculated mol wt 20.3 kDa |
| UniProt登记号 | P39900 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... MMP12(4321) |
安全信息
| 危险声明 | H412 |
| 预防措施声明 | P273 - P501 |
| 危险分类 | Aquatic Chronic 3 |
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich
m.cnreagent.com
