产品说明
应用
Merbarone has been used to study its effect on the occurrence of DNA lesions.
包装
25 mg in glass bottle
生化/生理作用
Thiobarbituric acid with aniline joined by an amide linkage forms merbarone. It is known to prolong cell cycle progression by inducing DNA double strand breaks, retarding S phase and arresting G2 phase. This delays cell entry into mitosis. Merbarone possesses cytotoxic and genotoxic action and promotes endoreduplication. Merbarone has mild antitumor action and is also found to nephrotoxic.
Selective topoisomerase II inhibitor. Blocks topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. Induces apoptosis in CEM cells via caspase 3 dependent mechanism.
基本信息
| 经验(实验)分子式 | C11H9N3O3S |
| 分子量 | 263.27 |
| MDL编号 | MFCD00866337 |
| PubChem化学物质编号 | 24724534 |
产品性质
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| drug control | regulated under CDSA - not available from sigma-aldrich Canada |
| 溶解性 | DMSO: >5 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | O=C1NC(=S)NC(=O)C1C(=O)Nc2ccccc2 |
| InChI | 1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18) |
| InChI key | JARCFMKMOFFIGZ-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
