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Anti-MDM2 antibody ,Mouse monoclonal

品牌
Sigma-Aldrich
货号
M7815
规格纯度
clone HDM2-323, purified from hybridoma cell culture
参考价格
5340.24 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-MDM2 antibody ,Mouse monoclonal
产品介绍:

产品说明

一般描述

Monoclonal Anti-MDM2 (mouse IgG2a isotype) is derived from the HDM2-323 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. MDM2 (the human homologue of Mdm2, a 90 kDa molecule), is a transcriptional target of p53.

免疫原

synthetic peptide corresponding to amino acids 389-402 of human MDM2 conjugated to KLH.

应用

Anti-MDM2 antibody, Mouse monoclonal has been used in western blotting and enzyme linked immunosorbent assay (ELISA).

生化/生理作用

MDM2 functions in the activation of p53 resulting in MDM2 expression, which consequently inhibits p53 transcriptional function. MDM2 accomplishes this inhibition in two ways: because of its physical interaction with p53, MDM2 both represses p53 transcriptional activity and mediates the degradation of p53. Overexpression of MDM2 results in reduced quantities of coexpressed p53, and disruption of the p53-MDM2 interaction by mutation results in both activation and accumulation of p53. MDM2 protein has been shown to activate cell proliferation by stimulating the S-phase-inducing transcription factors, E2F1/DP1.5 The amplification of the MDM2 gene has been demonstrated in various human neoplasms.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆HDM2-323, monoclonal
形式buffered aqueous solution
分子量antigen ~90 kDa
species reactivitymouse, human
浓度~2 mg/mL
technique(s)indirect ELISA: suitable
microarray: suitable
western blot: 1-2 μg/mL (whole cell extract of 293T cells transfected with human MDM2)
同位素/亚型IgG2a
UniProt登记号Q00987
运输dry ice
储存温度−20℃
Gene Informationhuman ... MDM2(4193)
mouse ... Mdm2(17246)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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