您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > Anti-MRP1 antibody ,Mouse monoclonal

Anti-MRP1 antibody ,Mouse monoclonal

品牌
Sigma-Aldrich
货号
M9192
规格纯度
clone QCRL-4, purified from hybridoma cell culture
参考价格
4330.86 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-MRP1 antibody ,Mouse monoclonal
Anti-Multidrug Resistance Associated Protein 1
产品介绍:

产品说明

一般描述

Multidrug resistance associated protein 1 (MRP1) is present in subcellular vesicles and is composed of 1531 amino acids. It has a molecular weight of 190kDa. The gene encoding MRP1 is localized in human chromosome 16p13.11.
Monoclonal Anti-MRP1 (mouse IgG1 isotype) is derived from the QCRL-4 hybridoma produced by the fusion of mouse myeloma cells (SP2/O) and splenocytes from mice. MRP1 protein belongs to the multidrug resistance-associated protein (MRP) subfamily of adenosine triphosphate (ATP)-binding cassette (ABC) transporters.

特异性

Does not cross-react with the human MDR1 and MDR3 proteins.

免疫原

non-denatured membrane preparations of H69AR human small cell lung cancer cell line, which highly expresses MRP1. The epitope resides within the second nucleotide-binding domain of human MRP1 between amino acids 1294-1531.

应用

Anti-MRP1 antibody, Mouse monoclonal may be used in:

  • noncompetitive capillary electrophoresis immunoassay (CEIA)
  • immunoblotting
  • flow cytometry
  • immunoprecipitation
  • transport inhibition

包装

200 μL in glass bottle

生化/生理作用

Multidrug resistance associated protein 1 (MRP1) functions in the metabolism of many drugs. It is involved in transporting different biomolecules and anticancer drugs like prostaglandins, glutathione, alkaloids and anthracyclines. MRP1 offers resistance against chemotherapy to cells in solid tumors.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

储存及稳定性

For continuous use, store at 2-8 ℃ for up to one month. For prolonged storage, freeze in working aliquots at −20 ℃. Repeated freezing and thawing is not recommended. Storage in frost-free freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD01865488
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆QCRL-4, monoclonal
形式buffered aqueous solution
分子量antigen ~190 kDa
species reactivityhuman
浓度~2 mg/mL
technique(s)flow cytometry: 0.5-2 μg/mL using human H69AR cells
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: suitable
同位素/亚型IgG1
UniProt登记号P33527
运输dry ice
储存温度−20℃
Gene Informationhuman ... ABCC1(4363)

Sigma-Aldrich

推荐产品