产品说明
一般描述
A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.
包装
2 mg in Glass bottle
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
Syk
Product competes with ATP.
Reversible: yes
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther.306, 1174.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C20H18N6O3 · xHCl · yH2O |
| 分子量 | 390.40 (anhydrous free base basis) |
产品性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | solid |
| 效能 | 10 nM IC50 |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | yellow |
| 溶解性 | DMSO: 10 mg/mL water: 20 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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