产品说明
应用
NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.
包装
5, 25 mg in glass bottle
生化/生理作用
NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.
Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor
基本信息
| 经验(实验)分子式 | C15H16ClN3O3 |
| 分子量 | 321.76 |
| MDL编号 | MFCD08276924 |
| PubChem化学物质编号 | 24724556 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 储存条件 | protect from light |
| 颜色 | red |
| 溶解性 | DMSO: ≥10 mg/mL H2O: insoluble |
| 储存温度 | 2-8℃ |
| SMILES string | ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O |
| InChI | 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2 |
| InChI key | BMKPVDQDJQWBPD-UHFFFAOYSA-N |
| Gene Information | human ... CDC25B(994), DUSP3(1845), PTPN1(5770) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | 470.1 °F |
| 闪点(C) | 243.4 ℃ |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich
m.cnreagent.com
