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Nucleozin

品牌
Sigma-Aldrich
CAS
341001-38-5
货号
N2790
规格纯度
≥98% (HPLC), powder
参考价格
1179.67 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
341001-38-5
Nucleozin
[4-(2-Chloro-4-nitro-phenyl)-piperazin-1-yl]-(5-methyl-3-phenyl-isoxazol-4-yl)-methanone
1-(2-Chloro-4-nitrophenyl)-4-[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]-piperazine
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

应用

Nucleozin may be used in anti-viral (anti-influenza) research to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an influenza A nucleoprotein (a multifunctional, RNA-binding protein necessary for virus replication) targeting drug candidate.

生化/生理作用

Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. Nucleozin is effective in fighting H1N1, H3N2, and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulation, leading to cessation of viral replication.
Nucleozin targets influenza A nucleoprotein, a multifunctional, RNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulation, interfering with viral replication. EC50 is in the nM range. Nucleozin is effective in H1N1, H3N2, and H5N1 flu virus strains.

基本信息

经验(实验)分子式C21H19ClN4O4
分子量426.85
MDL编号MFCD01426660
PubChem化学物质编号329818419
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 yellow
溶解性DMSO: >15 mg/mL
储存温度2-8℃
SMILES stringCc1onc(-c2ccccc2)c1C(=O)N3CCN(CC3)c4ccc(cc4Cl)[N+]([O-])=O
InChI1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3
InChI keyOWXBJAPOSQSWAO-UHFFFAOYSA-N

安全信息

储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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