NIDA-41020

产品名称：

502486-89-7
NIDA-41020
1-(2,4-Dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide

产品介绍：

产品说明

生化/生理作用

NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB₁ receptors, K_i = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have K_i of 0.6, 4.5 and 1.8 nM respectively].

基本信息

经验(实验)分子式	C₂₃H₂₄Cl₂N₄O₂
分子量	459.37
MDL编号	MFCD08277026
PubChem化学物质编号	329818682
NACRES	NA.77

产品性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
颜色	off-white
溶解性	DMSO: ~16 mg/mL H₂O: insoluble
储存温度	2-8℃
SMILES string	COc1ccc(cc1)-c2c(C)c(nn2-c3ccc(Cl)cc3Cl)C(=O)NN4CCCCC4
InChI	1S/C23H24Cl2N4O2/c1-15-21(23(30)27-28-12-4-3-5-13-28)26-29(20-11-8-17(24)14-19(20)25)22(15)16-6-9-18(31-2)10-7-16/h6-11,14H,3-5,12-13H2,1-2H3,(H,27,30)
InChI key	KWDBQJRWPWTGPF-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H300 - H315 - H319 - H335
预防措施声明	P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges