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Anti-Neurabin II (C-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
N5037
规格纯度
affinity isolated antibody, buffered aqueous solution
参考价格
6801.88 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Neurabin II (C-terminal) antibody produced in rabbit
Anti-Spinophilin
Anti-PP1bp134
Anti-Protein Phosphatase 1 Regulatory Subunit 9B
Anti-Neural-tissue Specific F-actin Binding Protein II
产品介绍:

产品说明

一般描述

Neurabin II belongs to a family of F-actin-binding proteins, highly enriched in dendritic spines and involved in neurite formation. It consists of an F-actin binding domain at the N-terminus, a single PDZ-interacting-domain and a C-terminal coiled-coil domain.

免疫原

synthetic peptide corresponding to amino acids 800-817 located at the C-terminal region of rat neurabin II. The sequence is identical in human and mouse neurabin II and not found in neurabin I.

应用

Anti-Neurabin II (C-terminal) antibody has been used in

  • immunoblotting
  • immunoprecipitation
  • immunocytochemistry

生化/生理作用

Neurabins appear to function as bridging proteins by targeting other proteins to the synapse or by linking plasma membrane proteins to the actin cytoskeleton. Neurabin II binds to several proteins including F-actin, protein phosphatase 1 (PP1), at least two subfamilies of G-protein coupled receptors (GPCRs), the α2 adrenergic receptor (α2AR) subtypes and the D2 dopamine receptor. Neurabin II blocks arrestin function in vitro and in vivo at GPCRs and has been also shown to modulate, in vitro and in vivo, both glutaminergic synaptic transmission and the formation and function of dendritic spines. Neurabin II and neurabin I target PP1 subunits that are highly concentrated in dendritic spines and post-synaptic densities. Phosphorylation of neurabin II modulates its interaction with actin filaments, via the anchoring of the neurabin II-PP1 complex within dendritic spines, thereby contributing to the efficacy and plasticity of synaptic transmission.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD02686629

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 140 kDa
species reactivitycanine, mouse, rat
technique(s)immunoprecipitation (IP): 10-20 μg using rat brain extract (S1 fraction)
indirect immunofluorescence: 10-20 using MDCK cells.
microarray: suitable
western blot: 1-2 μg/mL using mouse and rat brain extracts (S1 fraction)
UniProt登记号O35274
运输dry ice
储存温度−20℃
Gene Informationhuman ... PPP1R9B(84687)
mouse ... Ppp1r9b(217124)
rat ... Ppp1r9b(84686)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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