产品说明
一般描述
Osteopontin (OPN) is a multifunctional protein. It is released by macrophages, T cells and epithelial cells. It has 261 amino acid residues with a molecular mass of 29,283 Da. Osteopontin is also called as uropontin. Osteopontin from bovine milk is highly glycosylated and phosphorylated. SPP1 gene (secreted phosphoprotein 1) codes for osteopontin. This gene is located on human chromosome 4 and cow chromosome 6. It has seven exons and six introns.
生化/生理作用
Osteopontin stimulates cell mediated responses, chemotaxis of inflammatory cells and anti-inflammatory responses. It binds to av-containing integrins and stimulate cell adhesion and migration. Osteopontin promotes Th1 type immunity.
A secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells, and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig, and bovine OPN share 40% amino acid sequence identity.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
分析说明
The biological activity is measured by its ability to mediate 293 cell adhesion.
基本信息
| MDL编号 | MFCD03100698 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 100 |
| 生物来源 | bovine milk |
| 无菌性 | sterile |
| 形式 | lyophilized powder |
| 分子量 | ~60 kDa |
| 包装 | pkg of 50 μg |
| technique(s) | cell culture | mammalian: suitable |
| UniProt登记号 | P31098 P31096 |
| 运输 | ambient |
| 储存温度 | −20℃ |
| Gene Information | cow ... SPP1(281499) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
