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Anti-PERK (C-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
P0074
规格纯度
IgG fraction of antiserum, buffered aqueous solution
参考价格
4574.61 *本价格含增值税费
促销
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数量
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产品名称:
Anti-PERK (C-terminal) antibody produced in rabbit
Anti-E2AK3
Anti-HsPEK
Anti-EIF2AK3
Anti-WRS
Anti-PEK
Anti-Pancreatic eIF2α kinase
Anti-PRKR-like endoplasmic reticulum kinase
产品介绍:

产品说明

一般描述

Protein kinase RNA-like endoplasmic reticulum kinase (PERK) belongs to a family of eukaryotic initiation factor 2 α (eIF2α) kinases. It is a transmembrane kinase that is highly expressed in the pancreas. PERK contains two main domains: a kinase domain and an N-terminal domain like inositol- requiring enzyme-1 (IRE1), a protein involved in the unfolded protein response (UPR).
Protein kinase RNA-like endoplasmic reticulum kinase (PERK) is one of the three mammalian unfolded protein response (UPR) transducers. It is a highly conserved eukaryotic initiation factor 2 α (eIF2α) kinase. The gene encoding this protein is localized on human chromosome 2p11.2.

特异性

Anti-PERK C-terminal specifically recognizes PERK.

免疫原

synthetic peptide corresponding to amino acids 1078-1092 of mouse PERK, conjugated to KLH. This sequence is identical in rat and differs by one amino acid in human.

应用

Anti-PERK (C-terminal) antibody produced in rabbit has been used for western blotting and ERK (extracellular-signal-regulated kinase) phosphorylation assays.

生化/生理作用

Protein kinase RNA-like endoplasmic reticulum kinase (PERK) is an endoplasmic reticulum (ER) stress sensor which phosphorylates eukaryotic initiation factor 2 α (eIF2α), thereby reducing the translation of most messenger RNAs (mRNAs). In mice models of frontotemporal dementia, the suppression of translation in a PERK-eIF2α-dependent manner plays a key role in neuronal loss. PERK confers protection to heart against pressure overload-induced congestive heart failure. Mutations in this gene are linked with Wolcott-Rallison syndrome (WRS) which is characterized by permanent neonatal diabetes, exocrine-deficient pancreas, growth retardation and osteopenia.
Protein kinase RNA-like endoplasmic reticulum kinase (PERK) responds to distinct cellular stress signals.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~150 kDa
species reactivityhuman (predicted), mouse, rat
technique(s)western blot: 1:500-1:1,000 using whole cell lysate of HEK-293T expressing PERK cells
UniProt登记号Q9NZJ5
运输dry ice
储存温度−20℃
Gene Informationhuman ... Eif2ak3(13666)
mouse ... Eif2ak3(13666)
rat ... Eif2ak3(29702)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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