产品说明
一般描述
Potassium voltage-gated channel subfamily D member 3 (KCND3) gene codes for Kv4.3, an α-subunit of the Ito channel. It has seven exons and is mapped to the human chromosome 1p13.2. Kv4.3 is expressed in the brain and the heart. Anti-potassium channel Kv4.3 recognizes Kv4.3 protein in the rat by immunoblotting.
免疫原
synthetic peptide corresponding to amino acids 451-468 of rat or human potassium channel Kv4.3 (with additional N-terminal tyrosine and methionine replaced with norleucine).
应用
Anti-Potassium Channel Kv4.3 antibody produced in rabbit has been used in immunohistochemistry.
生化/生理作用
Potassium channels contribute to maintaining cell volume, neuronal excitability, and the secretion of transmitters, salt, and hormones. Potassium voltage-gated channel subfamily D member (Kv4.3) is involved in membrane repolarization in excitable cells. Kv4.3 may participate in the development of the cerebellum. It is capable of forming homo- or hetero-tetramers with the Shal subfamily channel members. KCND3 gene mutations result in Brugada syndrome and spinocerebellar ataxia type 22.
外形
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD02097221 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | lyophilized powder |
| species reactivity | human, rat |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable western blot (chemiluminescent): 1:200 |
| UniProt登记号 | Q9UK17 |
| 储存温度 | −20℃ |
| Gene Information | human ... KCND3(3752) rat ... Kcnd3(65195) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H312 + H332 - H412 |
| 预防措施声明 | P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 |
| 危险分类 | Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3 |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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