吡西卡尼盐酸盐

产品名称：

Pilsicainide Hydrochloride
SUN 1165
N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide Hydrochloride
Pilzicainide hydrochloride
吡西卡尼盐酸盐

产品介绍：

产品说明

应用

Pilsicainide hydrochloride has been used as a sodium channel blocker:

to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation
to study its effects on Ca²⁺ release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes
to study its electrophysiological effects on the guinea pig atrium

包装

10, 50 mg in glass bottle

生化/生理作用

Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na⁺¹ channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(⁺) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₁₇H₂₄N₂O · xHCl
分子量	272.39 (free base basis)
MDL编号	MFCD00903769
PubChem化学物质编号	329819981

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	deionized water: >5 mg/mL
储存温度	room temp
SMILES string	Cl.Cc1cccc(C)c1NC(=O)CC23CCCN2CCC3
InChI	1S/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H
InChI key	NZOSVDHCTCLGEB-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

Pilsicainide Hydrochloride

吡西卡尼 盐酸盐

吡西卡尼盐酸盐