06:0 Lyso PA

产品名称：

384835-45-4
06:0 Lyso PA
1-hexanoyl-sn-glycero-3-phosphate (ammonium salt); PA(6:0/0:0)

产品介绍：

产品说明

一般描述

Lysophosphatidic acid (LPA) belongs to a class of phospholipids, that has a glycerol backbone attached by a phosphate group, an aliphatic chain and a hydroxyl group. It has a phosphate group attached to sn-3 position, an aliphatic chain attached to sn-1 or sn-2 position and the hydroxyl group attached to the remaining sn-1 or sn-2 position. 06:0 Lyso PA/HHGP, belongs to the LPA (lysophosphatidic acid) family. It is a negatively charged single chain lipid.
Lysophosphatidic acid (LPA) has a free hydroxyl and phosphate moiety. It is hydrophilic and is not associated with the membrane. It is the major constituent of serum.

应用

06:0 Lyso PA (LPA) has been used in the structure-activity relationship (SAR) analysis with G-protein receptor GPR92. It has also been used in lipid assay in the treatment of serum-starved primary mouse embryonic fibroblast cells.
06:0 Lyso PA has been used to study the role of lipid binding to MxiM protein in co‐crystallization experiments.

生化/生理作用

Lysophosphatidic acid (LPA) participates in several biological functions. LPA stimulates platelet aggregation, chemotaxis, cytoskeleton rearrangement, Ca²⁺ mobilization and cell proliferation. 06:0 Lyso PA/HHGP possesses a micromolar binding affinity for global regulator of LEE (locus of enterocyte effacement) repressor (GrlR) and for β-lactoglobulin.
Lysophosphatidic acid (LPA) is the precursor for the synthesis of phospholipids in eukaryotes and prokaryotes. It acts as an intercellular signaling molecule. Activated platelets produce LPA. It plays a major role in tissue healing and wound regeneration. LPA binds to G-protein coupled receptors. It possesses mitogenic properties. LPA inhibits differentiation of neuroblastoma and myoblast, aids in neurotransmitter release and smooth muscle contraction. It is a potential biomarker for ovarian and gynecological cancers. It is implicated in the initiation of neuropathic pain.

包装

5 mL Amber Glass Screw Cap Vial (857119P-25mg)

基本信息

经验(实验)分子式	C₉H₂₂NO₇P
分子量	287.25
NACRES	NA.25

产品性质

测定	>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
形式	powder
包装	pkg of 1 × 25 mg (857119P-25mg)
manufacturer/tradename	Avanti Polar Lipids 857119P
运输	dry ice
储存温度	−20℃
SMILES string	O[C@](COP([O-])(O)=O)([H])COC(CCCCC)=O.[NH4+]

安全信息

储存分类代码

13 - Non Combustible Solids