Anti-PRMT1 antibody produced in rabbit

产品说明

一般描述

PRMT1 belongs to the family of protein arginine methyl transferases (PRMT). These enzymes transfer the methyl group from S-adenosyl-L methionine to the guanidino nitrogen atoms of an arginine residue. PRMTs are divided in two major types, I and II. It is also known as HRMT1L2 and IR1B4. PRMT1 was isolated through its interaction with BTG1 and TIS2, proteins that are important in cell quiescence. It is a 361 amino acids protein; its splicing variants differ at the N-terminus, giving rise to three isoforms (variants 1, 2 and 3).

免疫原

synthetic peptide corresponding to amino acids 326-341 of mouse PRMT1, conjugated to KLH via an N-terminal added cysteine residue. The sequence is conserved in human, and differs by one amino acid from the rat sequence.

应用

Anti-PRMT1 antibody produced in rabbit has been used in immunoblotting.

生化/生理作用

PRMT type 1 and 2 catalyze the formation of monomethylarginine, but differs in that Type I (including PRMT1, 3, 4, and 6) catalyzes the formation of asymmetric dimethylarginine, whereas type II (PRMT5) catalyzes the formation of symmetric dimethylarginine.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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