4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol; follicular fluid meiosis-activating sterol

产品名称：

64284-64-6
FF-MAS
4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol; follicular fluid meiosis-activating sterol

产品介绍：

产品说明

一般描述

Follicular fluid meiosis-activating sterol (FF-MAS) is an intermediate in the cholesterol biosynthetic pathway present in all cells, and may represent the physiological signal that instructs the oocyte to reinitiate meiosis.

应用

FF-MAS has been used:

as a standard in gas chromatography/ mass spectroscopy (GC/MS) for profiling sterols of oligodendrocyte progenitor cells (OPCs)
as Dulbecco′s modified eagle medium (DMEM) medium supplement to test its effect on cancer cell viability
to evaluate its effect on LXRβ-overexpressing squamous carcinoma SCC61 cells

生化/生理作用

14-demethyl-14-dehydrolanosterol (FF-MAS) was first identified in follicular fluid of women and plays a key role in oocyte nuclear maturation. The levels of FF-MAS may be regulated by cytochrome P450 family 27 subfamily A member 1. Supplementation of FF-MAS to oocytes promotes meiotic maturation favoring preimplantation. However, FF-MAS has low solubility and is metabolized to cholesterol rapidly.

包装

5 mL Amber Glass Screw Cap Vial (700077P-1mg)

基本信息

经验(实验)分子式	C₂₉H₄₆O
分子量	410.67
NACRES	NA.25

产品性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 1 mg (700077P-1mg)
manufacturer/tradename	Avanti Polar Lipids 700077P
运输	dry ice
储存温度	−70℃
InChI	1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1
InChI key	LFQXEZVYNCBVDO-PBJLWWPKSA-N

安全信息

储存分类代码

13 - Non Combustible Solids