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Anti-Protein Kinase Cβ2 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
P8371
规格纯度
affinity isolated antibody, buffered aqueous solution
参考价格
4330.86 *本价格含增值税费
促销
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数量
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产品名称:
Anti-Protein Kinase Cβ2 antibody produced in rabbit
Anti-PKCβ2
产品介绍:

产品说明

一般描述

Protein Kinase C (PKC, 76-93 kD) is a family of Ser/Thr specific protein kinases that perform key functions in numerous signalling pathways, in biological systems, through their various isoforms. The conventional PKC isoforms (cPKC) are PKC-α, β1, β2 and γ; activated by phosphatidylserine, calcium or phorbol esters. Proteolysis of PKC in vivo is thought to be mediated by calpains I and II. Calpains cleave PKC in the V3 hinge region to produce two distinct fragments, one comprising the N-terminal regulatory domain (30 kD) and the other fragment containing the C-terminal kinase domain (50 kD) that is catalytically active. Multiple functions such as, cellular and vascular regulations, angiogenesis, cell growth, apoptosis, changes in basement membrane thickness, extracellular matrix organisation, MAPK signalling, are attributed to PKC isoforms. These varied functions implicate PKC isoforms in cardiac hypertrophies and diabetic nephropathy and cardiovascular complications.
Anti-Protein Kinase C β2 antibody specifically recognises PKC β2 (80 kDa).

免疫原

synthetic peptide corresponding to amino acid residues 654-665 from human PKCβ2.

应用

Anti-Protein Kinase C β2 antibody may be used for detection by immunoblotting at a working concentration of 2μg/mL.

外形

Solution in phosphate buffered saline containing 1.0 mg/mL BSA and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00162771
NACRESNA.44

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityrat, human, mouse
technique(s)western blot: 2 μg/mL using recombinant human PKC beta II
UniProt登记号P05771
运输dry ice
储存温度−20℃
Gene Informationhuman ... PRKCB(5579)
mouse ... Prkcb(18751)
rat ... Prkcb(25023)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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