产品说明
一般描述
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) is an inadequate phospholipid present on the inner leaflet of the plasma membrane.
PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) is restricted to the cell membrane of inner leaflet. TopFluor® PI(3,4,5)P3 is a fluorescently labeled-phosphoinositide derivative containing saturated acyl chain.
生化/生理作用
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) plays a key role in inducing the cluster of Syntaxin1A at presynaptic terminals. It also regulates the activity protein kinase B/Akt.
PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) serves as a substrate for PTEN (phosphatase and tensin homolog), a tumor suppressor protein. It has binding affinity towards the active site of phosphatase domain. TopFluor® PI(3,4,5)P3 might be useful in monitoring protein induced phosphoinositide clustering. This product is considered photostable than other fluorophores.
包装
2 mL Amber Serum Vial with Stopper and Crimp Cap (810189P-50ug)
法律信息
TopFluor is a registered trademark of Avanti Polar Lipids, Inc.
基本信息
| 经验(实验)分子式 | C56H108 BF2 N7O23P4 |
| 分子量 | 1420.19 |
| NACRES | NA.25 |
产品性质
| 测定 | >99% (TLC) |
| 形式 | powder |
| 包装 | pkg of 1 × 50 μg (with stopper and crimp cap (810189P-50ug)) |
| manufacturer/tradename | Avanti Polar Lipids 810189P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
