产品说明
一般描述
Arterial endothelial cells play critical roles in cardiac homeostasis, and insults to the endothelial cells have been linked to a variety of vascular diseases. Porcine artery endothelial cells provide a useful tool to study artery endothelial function and metabolism.PCAEC from Cell Applications, Inc. have been used to investigate a new mechanism of obesity-associated vascular disease by demonstrating that resistin, an adipocyte-derived cytokine implemented in insulin resistance and diabetes, can cause endothelial dysfunction in coronary arteries through oxidative stress and down-regulation of NO synthase (Kougias, 2005). Conversely, secretoneurin was shown to activate expression of NO synthase and calmodulin, leading to endothelial relaxation (Chan, 2011). PCAEC were also used in adhesion and transmigration experiments in a study investigating anti-inflammatory, cardioprotective effects of a novel adenosine-lidocaine drug formulation (Shi, 2012).
细胞系来源
Artery
应用
cardiovascular function, angiogenesis, vascular biology, regulation of coronary blood flow, cardiac functions, effects of vaso-dilators, coagulation, fibrinolysis, vessel wall tone, cytokine production
组分
Porcine Endothelial Cell Growth Medium that contains 10% FBS and 10% DMSO
制备说明
传代培养常规
Please refer to the PCAEC Culture Protocol.
基本信息
NACRES | NA.81 |
产品性质
质量水平 | 100 |
生物来源 | Porcine coronary artery |
包装 | pkg of 500,000 cells |
生长模式 | Adherent |
核型 | 2n = 38 |
形态学 | Endothelial |
technique(s) | cell culture | mammalian: suitable |
相关疾病 | cardiovascular diseases |
运输 | dry ice |
储存温度 | −196℃ |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich