Ro 15-4513

产品名称：

91917-65-6
Ro 15-4513
Ethyl 8-azido-6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Ro15-4513

产品介绍：

产品说明

应用

Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies.

包装

25, 100 mg in poly bottle

生化/生理作用

Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.

特点和优势

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₁₅H₁₄N₆O₃
分子量	326.31
MDL编号	MFCD00078598
PubChem化学物质编号	24899343

产品性质

质量水平	100
形式	solid
颜色	tan
溶解性	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL H₂O: insoluble methanol: soluble
创始人	Roche
SMILES string	CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(ccc-23)N=[N+]=[N-]
InChI	1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3
InChI key	CFSOJZTUTOQNIA-UHFFFAOYSA-N
Gene Information	human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559) rat ... Gabrg1(140674)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)