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RO-52 (SSA) human

品牌
Sigma-Aldrich
货号
R8526
规格纯度
recombinant, expressed in E. coli, liquid
参考价格
5053.11 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
RO-52 (SSA) human
产品介绍:

产品说明

一般描述

RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5. It is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis. Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.

应用

RO-52 (SSA) human has been used:

  • as a component of the autoantigen array
  • to immobilise protein on the self-assembly monolayer
  • in enzyme-linked immunosorbent assays (ELISAs)

生化/生理作用

Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.

外形

solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.

基本信息

MDL编号MFCD03458409
NACRESNA.56

产品性质

质量水平200
重组expressed in E. coli
形式liquid
分子量 52 kDa by SDS-PAGE
technique(s)ELISA: suitable
UniProt登记号P19474
储存温度−70℃
Gene Informationhuman ... TRIM21(6737)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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