产品说明
一般描述
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5. It is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis. Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
应用
RO-52 (SSA) human has been used:
生化/生理作用
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.
外形
solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.
基本信息
MDL编号 | MFCD03458409 |
NACRES | NA.56 |
产品性质
质量水平 | 200 |
重组 | expressed in E. coli |
形式 | liquid |
分子量 | 52 kDa by SDS-PAGE |
technique(s) | ELISA: suitable |
UniProt登记号 | P19474 |
储存温度 | −70℃ |
Gene Information | human ... TRIM21(6737) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich