Monoclonal Anti-RAP1 antibody produced in mouse

产品说明

一般描述

Monoclonal Anti-RAP1 (mouse IgG2b isotype) is derived from the hybridoma 4C8/1 produced by the fusion of mouse myeloma cells (Sp2/0 Ag.14 cells) and splenocytes from BALB/c mice immunized with human RAP1. Ras-related protein 1 (RAP1) protein contains 399 amino acids with an acidic C-terminus featuring a 33 amino acid coiled-coil region and a bipartite nuclear localization signal. It is expressed ubiquitously, is located at telomeres and affects telomer length.
Rap1 (repressor/activator protein) is a constituent of shelterin. It consists of an N-terminal BRCT motif, a C-terminal protein interaction domain, and one or two central Myb domains. It is also known as Terf2ip (TERF2 interacting protein). It is located on chromosome 16q23.1.

免疫原

human RAP1.

应用

Monoclonal Anti-RAP1 antibody produced in mouse may be used in enzyme linked immunosorbent assay (ELISA) and immunoblotting.

生化/生理作用

Rap1 (repressor/activator protein) helps to guard telomeres, assemble telomerase, and controls telomere length. At telomeres, Rap1 also participates in the suppression of non-homologous end joining (NHEJ). It involves in genomewide transcriptional modulation. Knockdown of Rap1 induces apoptosis in hepatocellular carcinoma cell line HepG2.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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